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This includes decreasing IL-6, iNOS, TNF-, IL-1, MMP-1, and MMP-9 and upregulating VEGF, TGF-1 and TIMP-1 in patients with diabetic foot ulcers (191, 192)

Effective Fe 2 chelators can mitigate oxidative damage by sequestering iron, thereby preventing its participation in hydroxyl radical (HO) production through Fenton-type reactions

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It is necessary to enhance the development of integrated treatment strategies, promote interdisciplinary cooperation, and fully investigate the shared pathophysiological mechanisms to improve patient outcomes and quality of life

1995;10 Suppl 2:S8-24