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-A- D-Nle-Cys-Ile-NH-(CH 2 ) 5 -CONH 2s TM#TM D- Nle-Met-Ile-NH-(CH 2 ) 5 -CONH 2 D-Nle-Trp-Ile-NH-(CH 2 ) 5 - CONH 2 D-Nle-Trp-Ile-NH-(CH 2 ) 5 - CONH 2 FIG 24A and B Inhibition of HGF dimerization by D-Nle-X-IIe-NH-(CH 2 ) 5 -CONH 2 analogs

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This profile supports its application in research focused on alternative pain signaling mechanisms, including interactions with endogenous opioid peptides and neurochemical mediators such as substance P