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In addition, the polyol pathway becomes increasingly active under hyperglycemic conditions, with aldose reductase catalysing the reduction of glucose to sorbitol[9], impairing the cells antioxidant defences and exacerbating oxidative stress

This activation may occur due to regeneration and reparation processes as well as mitochondrial biogenesis (48)

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The overexpression of MFN2 enhances mitochondrial fusion to prevent mitochondrial fragmentation (96) and alleviates the decrease in mitochondrial membrane potential and excessive ROS induced by angiotensin II (97)

[DOI] [PubMed] [Google Scholar] 22.Ciftci H., Bakal U

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