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236,237 Furthermore, a comparison between DTP cells and their parental common cancer cells revealed that DTP cells display heightened sensitivity to GPX4 inhibition, increased levels of lipid ROS, elevated expression of reduced GSH-specific -glutamyl transferase 1 (CHAC1), and reduced expression of glutamate-cysteine ligase catalytic subunit (GCLC), indicating the necessity of GPX4 for DTP cells