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2019 Toonen LJA, Overzier M, Evers MM, Leon LG, van der Zeeuw SAJ, Mei H, et al

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Refrigeration at 4 C (39 F) extends shelf stability and is recommended for long-term storage
This implies sodium channel inhibition, a blockade of voltage-gated sodium channels (VGSCs) leading to a reversible block of action potential propagation [278], and reduced permeability of cell membranes, thereby blocking depolarization and preventing the conduction of the electrical impulse through which pain occurs [279]

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