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It is not really understood why cancers overexpress ALDOA over ALDOB, but it is reasonable to assume that this is because ALDOA exhibits much higher affinity for fructose-1,6-bisphosphate than ALDOB, and it does not require cleaving fructose-1-phosphate that originated from fructose, which is usually a property of ALDOB residing in the liver, the organ that will convert much of ingested fructose to glycolytic intermediates anyway 118

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EMT, Epithelial-Mesenchymal Transition