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doi: 10.1038/s41467-022-31933-w 85 ToubianaSGagliardiMPapaMMancoRTzukermanMMatarazzoMRet al

The activation of AREs is primarily controlled by the Nrf2/Keap1 signaling pathway, which plays a central role in cellular defense against oxidative stress

F., et al., Lipoic Acid Prevents High-Fat Diet-Induced Hepatic Steatosis in Goto Kakizaki Rats by Reducing Oxidative Stress Through Nrf2 Activation

Asanuma M, Miyazaki I, Diaz-Corrales FJ, Ogawa N

Remarkably, the TSS pathway is compensatively activated when the extracellular source of cystine is restricted or under extreme oxidative stress conditions

Cuddihy J, Wu G, Ho L, Kudo H, Dannhorn A, Mandalia S, et al