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The presence of endothelial NO synthase in human corpora lutea and the expression has been reported in the mid and early luteal phase and to a lesser extent in the late luteal [53]

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Hypothyroidism is classified as primary or secondary, with primary causes including iodine deficiency, autoimmune diseases (e.g., Hashimotos thyroiditis), enzymatic damage, radiotherapy, thyroid surgery, certain medications, and chronic or infiltrative conditions, while secondary hypothyroidism results from pituitary or hypothalamic disorders

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Abdelraheem et al