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Recent pilot studies and small clinical trials in people with diabetic neuropathy found improvements in blood flow to the skin and reductions in pain, though the number of patients studied has been small and treatment plans varied (Tassone et al., 2023)

This highlights the resolved corneal angiogenic privilege, a corneal avascular state known to be essential for cornea healing and transparency maintenance [122,123,124,125,126,127,128]

10, 4353 10.1038/s41467-019-12384-2 [DOI] [PMC free article] [PubMed] [Google Scholar] 57.Lurier E.B., Dalton D., Dampier W., Raman P., Nassiri S., Ferraro N.M.et al

The emotional burden of severe psoriasis, historically termed the heartbreak of psoriasis, can increase the risk of psychological disorders (Parisi 2013