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A recent meta-analysis validated that physical exercise significantly reduces fatigue in people with MS

Cephalalgia 22 , 624632 (2002)

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Vit-D could also inhibit NF-B activation to down-regulate proinflammatory cytokine synthesis and other key activators of cell-mediated immunity 692

Cheng HJ, Chen T

Improved exercise performance: Better fat utilization can help spare glycogen stores, allowing athletes to maintain performance for longer before fatigue appears