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Description
Side effects are typically mild injection-site reactions, flushing, increased heart rate, nausea, headache
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Compound 16 may be methylated using, for example, the general method outlined inScheme1 to give cation 2k
When NNMT is inhibited by compounds like 5-Amino-1MQ, more nicotinamide becomes available for conversion to NAD+ via NAMPT
The associated S plot (Fig 2A) indicated the NMR chemical shifts, then assigned to metabolites, that discriminated between the two classes (Figs 2C and S3)
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