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Symptoms must be taken seriously and addressed proactively [21]

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41 Other PDZ domain-containing scaffolding proteins, in addition to ZOs, including partitioning defective 3 (Par3), Par6, protein associated with Lin7 1 (PALS1), PALS1associated tight junction (PATJ), multi-PDZ domain protein 1 (MUPP), and afadin, have been implicated in TJ assembly as well as apico-basal polarity

Anatomically, the olfactory epithelium localization in the nasal cavity roof leads to difficult drug access to the targeted region