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Medicare spent over $1 trillion last year and is the single biggest fiscal issue for the nation policymakers shouldnt add major new expenditures without taking a hard look at how much benefit they provide not just in terms of claimed savings, but in total health outcomes relative to other options

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In a 12-month, two-phase trial, subcutaneously administered lixisenatide moderately reduced the progression of motor dysfunction in patients with early Parkinsons disease (PD) compared to placebo (Meissner et al., 2024)