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The selectivity arises from the peptides structure representing only the lipolytic region of growth hormone without the receptor-binding domains responsible for broader effects

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However, the parenteral route of administration has several drawbacks, since it is invasive, painful, and poorly accepted by patients, especially when prolonged or repeated use is required [5]

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When at least one follicle 14 mm of diameter was observed, pituitary suppression was initiated with a GnRH antagonist (0.25 mg of cetrorelix acetate, Cetrotide