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However, as expressed both in this review and by others there are concerns about the age dependent effects of metformin and in older organisms, including C.elegans, rodents and humans, the effects of metformin are variable and may be detrimental [see (202)]
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This functionality makes it particularly effective for patients unable to control their blood sugar through diet or exercise alone
346 High expression of miRNA-182-5p increases the permeability of the intestinal barrier and accelerates destruction of the intestinal barrier by suppressing the expression of Claudin-2
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