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[18] Additional absolute contraindications include severe hepatic impairment, unexplained vaginal bleeding, porphyria cutanea tarda, pregnancy, and hypersensitivity to estradiol or capsule excipients

The medication is unsuitable for people with a personal or family history of medullary thyroid cancer, Multiple Endocrine Neoplasia syndrome type 2, severe gastrointestinal disorders, or a history of pancreatitis

Astragalus polysaccharide alleviates type 2 diabetic rats by reversing the glucose transporters and sweet taste receptors/GLP-1/GLP-1 receptor signaling pathways in the intestine-pancreatic axis

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Its hard to overstate how backwards this is

Estrogen production and action