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In addition, the MAPK signaling pathway plays a crucial role in the inflammatory response associated with amino acid metabolism

Furthermore, L-carnitine is reported to lower the threshold for seizures in some individuals, especially those with a history of seizures, but no evidence to support this alleged effect has been found [58]

Mechanistically, the FH / sensitivity to ferroptosis has been attributed to dysfunctional GPX4, the primary cellular defender against ferroptosis [109]

It is of note that NF1 patients can develop this kind of tumors in 5% of cases, whereas in non-NF1 related patients with HPGL/PCC history NF1 mutations have been reported in tumor cells [48]

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