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42 With this extremely high concentration of circulating bilirubin, a therapeutic bilirubin-binding agent would need to reach an unreasonably high concentration in the blood in order to have a physiologically significant effect

Golubnitschaja O, Sargheini N, Bastert J

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The optimal approach depends on the specific peptide, target bioavailability, and tolerance for formulation complexity

Front Horm Res (2010) 38:508