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Studies have shown that the Trx and GSH/Grx systems are specific to different organelles in neurons and glial cells and regulate redox signaling and that thiol-disulfide bond conversion (GSH) occurs in two states: oxidized and reduced (Horibe et al., 2001)

Int J Mol Sci (2020) 21(21):7889

Although endoplasmic reticulum-resident selenoproteins are known to have a role in preserving endoplasmic reticulum homeostasis, a connection between coronavirus infection and endoplasmic reticulum-resident selenoproteins has not yet been established [74]