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In reproduction studies, no effects on fertility were found in rats given up to 24 mg/kg, which is 6 times, and approximately equal to, the MRHD on a mg/kg and mg/m 2basis, respectively

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All data are represented in boxplots where the middle line is the median, the lower hinge is the 25 th percentile (i.e., first quartile), the upper hinge is the 75 th percentile (i.e., third quartile), the lower whisker extends to 1.5 the interquartile range (IQR) from the first quartile, the upper whisker extends to 1.5 IQR from the third quartile, and the data points beyond the end of the whiskers are individually plotted outliers

USA 119 , e2202934119 (2022)