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The health website Love to Know reports that the peripheral neuropathy in the legs may feel like muscle cramps or simple deep leg pain, numbness or tingling

This high distribution in the nervous system suggests that methylcobalamin is of central importance here, which is why methylcobalamin is the form preferred by many therapists for treating neurological symptoms

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the FDA has stated it lacks sufficient information to know whether the substance would cause harm when administered to humans Evidence snapshot: The evidence base is almost entirely preclinical, decades of animal (largely rat) studies, mostly from one Croatian research group (Sikiric et al., University of Zagreb), with a single small human trial under the brand name "Bepecin" (around 2015) that did not lead to any FDA-approved use

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Cobalt toxicity in humans-a review of the potential sources and systemic health effects