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It has been demonstrated that hyperglycemia induces damage to mitochondrial DNA, further impairing oxidative phosphorylation and ATP production, and that this damage accelerates the aging of high-energy-demanding tissues such as the cochlea and kidneys (Forbes and Thorburn, 2018)

Oxidant-induced glutathionylation at protein disulfide bonds

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A.AzarbarzinA.MarquesM.de MeloC.et al (2017b)

3) that is differentially processed dependent on the tissue in which it is expressed

higher ROS levels contribute to a condition called oxidative stress, which can cause liver cell damage