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Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages

In contrast to GSH synthesis, which occurs intracellularly, GSH degradation occurs exclusively in the extracellular space, and in particular, on the surface of cells that express the ectoenzyme -glutamyl transpeptidase (also called -glutamyl transferase or GGT) (Figure 1C)

doi: 10.1177/0960327120914977 [DOI] [PubMed] [Google Scholar] 53.Tsuchiya Y, Nakajima M, Yokoi T

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