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Mass cytometry and single-cell RNA sequencing analyses revealed a substantial increase in CD8+ T cells in the liver following AST treatment, with downregulated expression of functional markers, such as CD69, MHC II, and PD-1

Liu S, Gao J, Liu K, Zhang HL

Importantly, both interventions increase both lifespan and healthspan without apparent major fitness trade-offs, in contrast to those previously reported in long-lived mutants that do slow the rate of aging (Jenkins et al., 2004