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Role of oxidative stress in epileptic seizures

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Abstract The sulfur biochemistry of the thiol group endows cysteines with a number of highly specialized and unique features that enable them to serve a variety of different functions in the cell

(2) addition of aromatic groups to enhance hydrophobic interactions and spatial hindrance, thereby preventing C-loop closure and inhibiting calcium ion channel function [265,266,267,268]

Moreover, up-regulation of FABP1 protein along with up-regulation of PPAR-regulated gene transcripts (i.e., Acot2 and Acot4) is indicative of PPAR activation, which may contribute to hepatocellular protection against glutathione depletioninduced oxidative stress