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However, for nebulized antibiotics the interpretation of the antibiogram should take into consideration that, through this form of delivery, antibiotic achieves much higher concentrations in the bronchial mucosa overcoming the mechanisms of resistance.77 The persistence of bacteria despite aggressive treatment is thought to be due to several factors such as poor penetration of antibiotics into purulent airway secretions, native or acquired antibiotic resistance and production of biofilms by the bacteria that may render antibiotics ineffective or interfere with host defences

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And studying the methylation cycle, in combination with other biological cycles can provide invaluable clues to assist in recovery from numerous states of disease

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14,22 Dysbiosis, or imbalance in the composition and/or function of this microbial community, has been strongly associated with GI diseases 6 as well as systemic conditions via its influence on other organs through the numerous gut-organ axesemphasizing the gut's interconnectedness with broader health processes