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Cell therapeutics in Parkinsons disease

In cells with intact KEAP1-NRF2 system, transiently stabilized NRF2 induces transcriptional activation of genes encoding xCT, SLC7A11 , and two subunits of gamma-glutamylcysteine ligase (GCL), GCLC and GCLM , in response to oxidative and electrophilic stresses

J Clin Investig 134(12):e172436

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others titrate upward per the label schedule

In the EzColocalization plugin, an automated threshold was set for the TOMM20 signal, whilst threshold of the p62 channel was set using background signal from the p62 channel in WT cells