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To reduce the development of drug-resistant bacteria and maintain the effectiveness of sulfamethoxazole and trimethoprim injection and other antibacterial drugs, sulfamethoxazole and trimethoprim injection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria

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This shift should involve standardized assessment tools, population-specific interventions, and a more comprehensive approach to studying the potential reversibility of early-stage graying