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While cat2 gr1 undergoes leaf bleaching when grown in long days, this effect is associated with repression rather than stimulation of SA-dependent pathogen responses (Mhamdi et al., 2010a), even though a wide range of these responses is associated with the less marked glutathione oxidation observed in cat2 single mutants (Chaouch et al., 2010)

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This suggests that sesamin directly quenched ROS and alleviated oxidative burden, making an extreme upregulation of catalase unnecessary

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A 2023 pharmaceutical review cautioned that BPC-157 increases VEGFR2 expression and that VEGF pathways are active in many human cancers

18 BPC-157 markedly improved rat sciatic nerve healing