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Phase I trial and pharmacological study of a 3-hour paclitaxel infusion in children with refractory solid tumours: A SFOP study

Abbreviations BMAL1: brain and muscle Arnt-like protein 1 CAT: catalase CLOCK: circadian locomotor output cycles kaput CRY: cryptochrome FFA: free fatty acids GDF11: growth differentiation factor 11 GPR50: G protein coupled receptor 50 GR: glucocorticoid receptor GPx: glutathione peroxidase GST: glutathione S transferase IRS-1: insulin receptor substrate 1 NQO1: NAD(P)H quinone dehydrogenase 1 Nrf2: nuclear factor erythroid 2-related factor 2 PER: period circadian protein PGC-1: peroxisome proliferator-activated receptor gamma-coactivator-1 PP2A: protein phosphatase 2 REV-ERB: reverse erythroblastosis virus ROR: retinoid-related orphan receptor ROS: reactive oxygen species SCN: suprachiasmatic nucleus SIRT1: sirtuin 1 SOD: superoxide dismutase References Fagiani F, Di Marino D, Romagnoli A, Travelli C, Voltan D, Mannelli LDC, Racchi M, Govoni S, Lanni C (2022) Molecular regulations of circadian rhythm and implications for physiology and diseases

PPARs/ were described as impactful in a group of society-haunting diseases such as obesity, atherosclerosis, diabetes, and cancer [98, 99]

FABP3, fatty acid binding protein 3

What are the benefits and dangers of AID-9604 (Acute Insulin-like Drug 9604)?
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