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Epigenetics, epidemiology and mitochondrial DNA diseases

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doi: 10.1101/cshperspect.a026211

Due to their close evolutionary relationship, rodents exhibit a high degree of genetic, biological, and neuroanatomical conservation with humans, including similar brain circuit pathways and neurotransmitter distribution, which underlie comparable behavioral phenotypes [10]

Thus, our results suggested that Sirt6-Tg mice are protected from hepatocyte necrosis and apoptosis triggered by APAP
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