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Research indicates that topical GHK-Cu can support regulation of skin tone by promoting collagen and elastin synthesis and modulating inflammatory responses

Paine C, Sharlow E, Liebel F, Eisinger M, Shapiro S, Seiberg M

Nat Rev Cancer 22(7):381396 Li X, Liu Y, Zheng Q, Yao G, Cheng P, Bu G, Xu H, Zhang Y-W (2013) Ferritin light chain interacts with PEN-2 and affects -secretase activity

They found that weak (r ~ 0.1) but significant correlations exist

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To understand why this goes beyond temporary discomfort, it helps to look at the emerging field of GLP-1 microbiome science , particularly how your gut bacteria respond to these medications and the central role of a bacterium called Akkermansia muciniphila