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In a randomized, double-blind, placebo-controlled trial in 2,919 participants (65 years) with elevated blood concentrations of homocysteine, supplementation with vitamin B 12 (500 g/day) and folic acid (400 g/day) for two years did not decrease the risk of osteoporotic fracture despite reductions in homocysteine (120, 121)

[DOI] [PubMed] [Google Scholar] 291.Singh, A

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Therefore, the surveillance of SAM by mitochondria at the site of bioenergetics and biosynthesis might have been effective for microorganisms in the metric of evolutionary fitness