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In 2023, Zhangs group reported two innovative tumor hypoxia-activated PROTACs 59 and 60 targeting epidermal growth factor receptor 19 deletions (EGFR DEL19 )
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Lack of shared neoantigens in prevalent mutations in cancer
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Yet, in G6PD def , metabolic reprogramming is insufficient to restore GSH levels towards those seen in G6PD WT individuals [64]
