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(Luo et al., 2022) addressed this by using ECM-modified hydrogels (ECM-Gels) to load cartilage endplate stem cells (CESCs) overexpressing sphingosine kinase 2 (Sphk2)

68,69,70,71,72,73,74 Genetic factors have also been suggested

The hippocampal tissue was disrupted using a T10 Ultraturrax homogenizer (IKA Werke GmbH) followed by RNA extraction with TRIzol Reagent (Invitrogen, Thermo Fisher Scientific) according to the manufacturers instructions

Ginger processed at 50C for 1 h exhibited the strongest macrophage activation by increasing the levels of IL-6 and TNF- and IL-6, whereas samples processed by freeze-drying at 70C and 90C demonstrated little effect