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Additionally, factors such as diet and exercise may also impact weight

The greatest challenge therefore consists of developing therapies capable of achieving efficient delivery of the recombinant enzyme in the CNS across the BBB

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Titration Flexibility: Why Your Dose Timeline May Differ While the standard protocol progresses every four weeks, clinical practice often deviates based on tolerability, gastrointestinal response, and individual efficacy goals

This results in the potential for drug-drug interactions when bupropion is co-administered with drugs metabolized by Cyt 2D6 (which includes many antidepressants, antipsychotics, beta blockers and Class IC antiarrhythmics) (rxlist.com side - drug interactions)