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For patients seeking weight loss who request B12 injections, GPs should: Assess for genuine deficiency through appropriate blood tests rather than empirical treatment Provide education about the lack of evidence supporting B12 for weight loss in non-deficient individuals Explore underlying concerns about weight and energy levels, addressing these through appropriate channels Signpost to evidence-based resources such as NHS weight management services according to local pathways Patients should contact their GP if they experience unexplained fatigue, neurological symptoms (numbness, tingling, balance problems), or signs of anaemia (pallor, breathlessness, palpitations), as these may indicate B12 deficiency requiring investigation

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2 Oxidative stress and periodontitis 2.1 Basic concepts of oxidative stress Oxidative stress refers to an imbalance between the production of reactive oxygen types (involving superoxide anions, hydrogen peroxide, etc.) and other oxidants in the cellular and extracellular environment, capable of damaging cell structures and functions ( Under normal conditions, the body regulates and neutralizes these parlous oxidants by antioxidant systems (including superoxide dismutase, glutathione peroxidase, etc.), remaining redox balance within cells (Menzel et al., 2021)

Meta-analyses support HbA1c reduction in diabetic populations, but a separate meta-analysis found no impact in individuals without diabetes

[DOI] [Google Scholar] Chou I-M

Anders als bei Sedativa entsteht keine knstliche Mdigkeit