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This impairment could result in irreparable damage to the percentage of oocytes that progress past the cleavage stage, leading to a subsequent decline in embryo developmental potential 49

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Relevant to a discussion of GPx-1 in cancer, evidence from experimental mouse models suggests that, at least for some cancers, selenium is protective, in part, through GPx-1, although expression of other selenoproteins will be modulated by a range of dietary Se concentrations (98, 182)

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