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Hence ROS-induced decline in circulatory NO secondary to endothelial dysfunction impairs the growth of the capillary network and blood flow regulation and subsequent diminution of microcirculation in metabolically active tissues and dysregulations of glucose and dyslipidaemia

Glucose, the primary carbon fuel for most lymphocytes, is converted into pyruvate in the glycolytic pathway

Emerging evidence implicates ferroptosis in the pathogenesis of depression (Dang et al., 2022

doi: 10.1210/en.2007-0239

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