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Serum testosterone fell to castration levels on day 2 but was inhibited only by 6470% during maintenance therapy, and returned to normal after cessation of treatment

Glutathione, (pronounced glue-tah-thigh-own!) is an antioxidant composed of three separate amino acids

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Finally, cells were washed and resuspended in flow cytometry buffer for analysis on BD LSRFortessa X-20

Mice were treated as described earlier, and survival was assessed daily

The ZSWIM8CUL3ARIH1 E3E3 assembly was required, as polyubiquitylation was not achieved with other canonical CRLRBR E3E3 partnerings (ZSWIM8CUL2ARIH1 or ZSWIM8CUL5ARIH2) 35,36,39 (Fig