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Introduction Methamphetamine (MA), a central nervous system (CNS) stimulant, is the third most used recreational drug world-wide ( The notion that MA might damage the human brain is derived primarily from preclinical animal data showing that high doses of MA, or its related stimulant amphetamine, cause loss of brain dopamine neuronal markers ( Although the precise mechanism(s) by which high doses of MA cause brain damage in preclinical studies remain uncertain, excessive oxidative stress is a likely candidate

They consume enormous amounts of NAD+ in the process

Luengo A, et al

Sales of approximately $31 billion are forecast, driven by its use in a wide range of cancer indications and active clinical development

Nat Struct Mol Biol 33 , 838852 (2026)

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