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Therefore, even if PHD-2 is inactivated by competitive inhibition of -ketoglutarate by pyruvate, FIH-1 remains active and prevents HIF-1 transcriptional activity (Rani et al., 2022)

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The blend's hypothesized potential to impact protein synthesis and cellular proliferation may provide a foundation for exploring how cellular aging impacts tissue repair and regeneration

doi: 10.1158/0008-5472.Can-20-0600 197 QieSChuCLiWWangCSangN