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Thus, hyperhomocysteinemia-induced NLRP3 inflammasome activation is mainly through ROS generation, cholesterol biosynthesis, and generation of oxLDL

Barton AR, Sherman MA, Mukamel RE, Loh P-R (2021) Whole-exome imputation within UK Biobank powers rare coding variant association and fine-mapping analyses

In vitro studies have found that in IDH1 mutant glioma stem cells (TS603), the expression of genes related to ROS clearance is overall upregulated, and the gene that regulates glutathione synthesis, SLC7A11, is most upregulated

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Notably, lactate-derived lactylation correlates with higher S-AKI incidence and poor prognosis in clinical sepsis patients