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Emery, P., So, W

Rajman L, et al

Zhu T., Zhang H., Li S., Wu K., Yin Y., and Zhang X., Detoxified Pneumolysin Derivative A146Ply Inhibits Autophagy and Induces Apoptosis in Acute Myeloid Leukemia Cells by Activating mTOR Signaling, Experimental & Molecular Medicine 54, no
B-class plexins regulate several small GTPases, interacting with Rac [21], Rnd1-2-3 [22], R-Ras [23], M-Ras [24] and RhoD [25] and regulating Rho via PDZRhoGEF/LARG [26] and p190RhoGAP [27]

In the case of ADCs, conjugating the antibody carriers to the native drugs substantially increases the size of the molecule, which impairs the penetration and bioavailability of the drugs in the tumors 17

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