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IGF1 is one of the most potent natural activators of the Akt signaling pathway, a stimulator of cell growth and proliferation, and a potent inhibitor of programmed cell death

10.1007/s11095-010-0076-z 55 KawanoH.HiguchiF.MayumiT.HamaT

10.1016/j.semcancer.2017.11.001 Semin Cancer Biol

developed an electrospun DegraPol tube delivering secretome from a co-culture of adipose-derived stem cells and tenocytes for Achilles tendon repair in rabbits, showing that this cell-free implant significantly reduced adhesion formation (22%), lowered tendon swelling (32% cross-sectional area), and restored near-native load and stiffness, demonstrating its strong potential as a biodegradable, secretome-releasing scaffold to enhance tendon healing and biomechanics (Rieber et al., 2025)

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Rising cases of iodine deficiency and autoimmune thyroid conditions such as Hashimotos disease further escalates the need for targeted nutritional support