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Lactate is cleared either by oxidizing to pyruvate for re-entry into the TCA cycle or by converting back to glucose in the liver and skeletal muscle via the Cori cycle [13, 14]

[DOI] [PubMed] [Google Scholar] 170.Gan Z, Fu T, Kelly DP, Vega RB

Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70

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This pathway typically suppresses NF-B activation and NLRP3 inflammasome activity, leading to reduced production of key pro-inflammatory cytokines (e.g., TNF-, IL-6, IL-12) by macrophages and DCs (77, 96)