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Liver sinusoidal endothelial cells - gatekeepers of hepatic immunity

J Reprod Med 53(7):499512 Riccetti L, Pignatti E, Simoni M

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The diminished accumulation of GSAAT attributable to TRX-f1 and NTRC deficiency results in a decrease in the flow of metabolites through the TBS pathway, and a correspondingly lower Chl content ( Figures 4A, B, E, F ), but does not alter the Chl a/b ratio ( Figure 4C )

Heme oxygenase 1 (HO-1) is an NRF2 target gene that prevents FH deficiency-mediated succinate stagnation through the heme synthesis and degradation pathway ( BEYOND REGULATING REDOX HOMEOSTASIS: NRF2 PROMOTES ANABOLIC PATHWAYS IN CANCERS In addition to coordinately activating the genes encoding detoxifying enzymes and antioxidant proteins, the constitutive accumulation of Nrf2 confers chemo- and radio-resistance for cancer cell survival