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Among genetic factors that contribute to different activity in response to clearance of oxidative stress products among individuals are the glutathione S-transferase (GST) gene polymor- phisms

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355,356,357 Giredestrant, despite not reaching statistical significance for the primary endpoint of investigator-assessed PFS in the acelERA BC phase 2 study, demonstrated comparable efficacy to the physicians choice of endocrine monotherapy in key subgroups and showed a beneficial trend in the ESR1 -mutant population