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Altered gut microbiota can signal through pattern recognition receptors on gut epithelial cells, activating the NF-B pathway and leading to changes in gut homeostasis [122]

This mechanism increases intracellular concentrations of both NAD+ and SAM, two fundamental molecules that regulate cellular energy expenditure, mitochondrial function, and epigenetic modifications

These beneficial effects of BPC 157 therapy [152,153,154,155] contrast with the use of agents that particularly promote epithelial growth, a widely acknowledged fear of inappropriate levels of proliferation, or, potentially carcinomatous changes, either within the gastrointestinal tract or elsewhere [156]

A useful way to think about it: in the research literature, BPC-157 is associated with building the supply lines new blood vessels and connective tissue at a specific site while Thymosin Beta-4 is associated with getting repair cells to move to where they are needed and remodel the tissue

82 Sheehan, p

Three other points warrant mentioning