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A higher level of oxidative stress was detected in patients with NASH compared to NAFLD and a reduction in the levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and GGT, as markers of oxidative stress, was highlighted in NASH patients treated with GSH, with a consequent reduction of alanine transaminase (ALT)

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These are triggered by: resistance training mechanical tension muscle damage So muscle growth involves both: Systemic IGF-1 (from the liver) + Local IGF-1 (within muscle tissue) Simple Summary of the Pathway Hypothalamus GHRH signalling Pituitary releases GH GH stimulates liver Liver releases IGF-1 IGF-1 activates mTOR signalling Muscle protein synthesis and hypertrophy Why Peptides Are Studied in This Context Many peptides used in research interact with different parts of this signalling pathway

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Cytoprotective Effects : MSCs also exhibit cytoprotective effects, safeguarding cells from harmful agents, potentially beneficial in PTLDS where ongoing immune responses might damage cells